Outreach + Highlights
The AGP laboratory conducts research on the diversity and biological evolution of human populations, with the main objective of reconstructing the history of world settlement since the origin of Homo sapiens.
Cryptic Biological Invasions: a General Model of Hybridization
The dispersal of non-native genes due to hybridization is a form of cryptic invasion with growing concern in evolution and conservation.
Genetic history of the African Sahelian populations
In collaboration with two other European research groups, the two laboratories of the Anthropology Unit, AGP and APA have just published a Review paper on the Genetic history of the African Sahelian population.
6th Annual Meeting of iGE3
Organisé par Marguerite Neerman-Arbez et Alicia Sanchez-Mazas.
HLA-B molecular variation and its links with malaria in Africa
The group of Alicia Sanchez-Mazas identified two HLA-B alleles as candidates to Plasmodium falciparum malaria protection in Africa.
Des précisions sur le mode de vie de nos cousins néandertaliens
Des chercheurs de l’Institut Max Planck ont procédé à l'analyse génétique d’une néandertalienne qui vivait sur le territoire de la Croatie actuelle il y a 52'000 ans.
La révolution génomique à l'honneur
Le Dr Mathias Currat s'exprime à la radio dans le cadre de la 17e édition du colloque Wright qui a pour thématique "La génomique, soit l’étude du fonctionnement de la vie à l’échelle du génome. En d’autres termes, le mode d’emploi du vivant”.
HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present larger repertories of peptides than homozygotes.
Prof. Alicia Sanchez-Mazas appointed Section Editor of HLA
Prof. Alicia Sanchez-Mazas was appointed Section Editor of HLA (previously Tissue Antigens), the official journal of the European Federation for Immunogenetics (EFI), and is in charge of the “HLA polymorphism in populations” Section.
Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa
Dietary changes associated to shifts in subsistence strategies during human evolution may have induced new selective pressures on phenotypes, as currently held for lactase persistence. Similar hypotheses exist for arylamine N-acetyltransferase 2 (NAT2) mediated acetylation capacity, a well-known pharmacogenetic trait with wide inter-individual variation explained by polymorphisms in the NAT2 gene.
Computer simulation of human leukocyte antigen genes supports two main routes of colonization by human populations in East Asia
Recent genetic studies have suggested that the colonization of East Asia by modern humans was more complex than a single origin from the South, and that a genetic contribution via a Northern route was probably quite substantial.