Rayonnement
Le laboratoire AGP mène des recherches sur la diversité et l'évolution biologique des populations humaines, avec pour objectif principal de reconstituer l'histoire du peuplement du monde depuis l'origine de l'Homo sapiens.
The wings of a “genetic bird” protect us against viruses
UNIGE researchers have demonstrated that every population can protect itself against a broad range of viruses thanks to the two most diverse HLA immune genes in humans.
Harmonizing hybridization dissonance in conservation
A dramatic increase in the hybridization between historically allopatric species has been induced by human activities. Our article proposes a novel view of conservation guidelines, in which human-induced hybridization may also be a tool to enhance the likelihood of adaptation to changing environmental conditions or to increase the genetic diversity of taxa affected by inbreeding depression.
Christelle Vangenot, Médéric Mouterde, Alicia Sanchez-Mazas et Estella Poloni ont fait la couverture du journal “G3” : la maîtrise du feu a-t-elle influencé la diversité génomique humaine ?
Cette hypothèse est avancée dans une étude récente qui a mis en évidence une évolution divergente entre l’humain et le chimpanzé dans une petite famille de gènes impliqués dans la détoxification des molécules produites lors de la combustion de matières organiques.
Hybridization and introgression during density-dependent range expansion: European wildcats as a case study
Hybridization models during range expansion have been developed but assume dispersal to be independent from neighboring population densities.
Bayesian estimation of partial population continuity using ancient DNA and spatially explicit simulations
We present a new spatially explicit computer simulation approach to estimate partial population continuity through time using ancient DNA.
Cryptic Biological Invasions: a General Model of Hybridization
The dispersal of non-native genes due to hybridization is a form of cryptic invasion with growing concern in evolution and conservation.
Genetic history of the African Sahelian populations
En collaboration avec deux autres équipes de recherche européennes, les deux laboratoires de l'Unité d'anthropologie, l'AGPet l'APA viennent de publier ensemble un article de revue sur l'histoire génétique des populations africaines du Sahel.
HLA-B molecular variation and its links with malaria in Africa
The group of Alicia Sanchez-Mazas identified two HLA-B alleles as candidates to Plasmodium falciparum malaria protection in Africa.
HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present larger repertories of peptides than homozygotes.
Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa
Dietary changes associated to shifts in subsistence strategies during human evolution may have induced new selective pressures on phenotypes, as currently held for lactase persistence. Similar hypotheses exist for arylamine N-acetyltransferase 2 (NAT2) mediated acetylation capacity, a well-known pharmacogenetic trait with wide inter-individual variation explained by polymorphisms in the NAT2 gene.