Rayonnement
Le laboratoire AGP mène des recherches sur la diversité et l'évolution biologique des populations humaines, avec pour objectif principal de reconstituer l'histoire du peuplement du monde depuis l'origine de l'Homo sapiens.
Benchmarking the Mantel test and derived methods for testing association between distance matrices
Testing the association between objects is central in ecology, evolution, and quantitative sciences in general.
Genetic surfing during the range expansion of an endangered large carnivore
In an effort to halt the global decline of large carnivores, reintroductions have become increasingly popular to establish satellite populations and reduce the risk of stochastic events.
Temporal variation in introgressed segments’ length statistics computed from a limited number of ancient genomes sheds light on past admixture pulses
Hybridization is recognized as an important evolutionary force, but identifying and timing admixture events between divergent lineages remains a major aim of evolutionary biology.
Past human expansions shaped the spatial pattern of Neanderthal ancestry
The worldwide expansion of modern humans (Homo sapiens) started before the extinction of Neanderthals (Homo neanderthalensis). This study shows that inferences about past human population dynamics can be made from the spatiotemporal variation in archaic introgression.
Joint Analysis of Phenotypic and Genomic Diversity Sheds Light on the Evolution of Xenobiotic Metabolism in Humans
Les médecins constatent souvent que leurs patients peuvent réagir différemment à un même traitement médical : pour certains, le médicament s'avère inefficace, alors que chez d'autres patients, il provoque des effets secondaires, parfois assez graves.
Population designations in biomedical research: Limitations and perspectives
In biomedical research, population differences are of central interest. Variations in the frequency and severity of diseases and in treatment effects among human subpopulation groups are common in many medical conditions.
Regards d'une généticienne sur les habitant de l'Islande
La manière dont les organismes vivants ont évolué au cours du temps laisse des marques, des signatures dans leur ADN.
Ancient mitochondrial diversity in Neolithic Greece and along the Danubian expansion axis
This study investigates mitochondrial diversity in Neolithic Greece and its relation to hunter-gatherers and farmers who populated the Danubian Neolithic expansion axis.
Spatially explicit paleogenomic simulations support cohabitation with limited admixture between Bronze Age Central European populations
Spatially explicit simulations of population dynamics combined with palaeogenomic data support the cohabitation of pastoralist and agriculturalist populations in Central Europe during the Bronze Age, with limited gene flow between them and a demographic decline after their initial contact.
Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present larger repertories of peptides than homozygotes.